The Norman Transcript

Headlines

Discussion

October 9, 2012

Alzheimer drug shows some promise in mild disease

The Associated Press Associated Press

BOSTON — Combined results from two studies of an experimental Alzheimer’s drug suggest it might modestly slow mental decline, especially in patients with mild disease.

Taken separately, the studies on the drug — Eli Lilly & Co.’s solanezumab — missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living. But pooled results found 34 percent less mental decline in mild Alzheimer’s patients compared to those on a fake treatment for 18 months.

Doctors called the results encouraging although probably not good enough to win approval of the drug now, without another study. Investors were more enthused, driving Lilly’s stock up about 5 percent Monday and about 19 percent since August.

Detailed results were revealed for the first time Monday at an American Neurological Association conference in Boston.

“It’s certainly not the home run we all wanted, but we’re very encouraged by these results,” said Maria Carillo, chief science officer for the Alzheimer’s Association.

Dr. Stephen Salloway, an Alzheimer’s expert at Brown University, agreed.

“It’s exciting to see that there may be clinical benefit,” he said, but it is modest and may not make a difference in how well patients live — what matters most to them and their families.

About 35 million people worldwide have dementia, and Alzheimer’s is the most common type. In the U.S., about five million have Alzheimer’s. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

Solanezumab is one of three drugs in late-stage testing that seek to alter the course of the disease. Results on one drug were disappointing, and results of the other won’t be ready until early next year.

Solanezumab aims to bind to and help clear the sticky deposits that clog patients’ brains. The two studies each had about 1,000 patients, about two-thirds with mild disease and one-third with moderately severe Alzheimer’s, in 16 countries. Their average age was 75.

The main measures were two tests — one reflecting language, memory and thinking and the other, ability to perform daily activities such as eating and grooming. The combined results on the mild disease patients showed a nearly two-point difference in the roughly 90-point score on thinking abilities. Previous studies suggest that a change of three to four on the score is needed to show a clinical benefit.

For local news and more, subscribe to The Norman Transcript Smart Edition, or our print edition.

Text Only | Photo Reprints
Headlines
  • Moore Tornado Moore open for business

    Until an EF-5 tornado carved a path through the economic core of Moore on Monday, sales tax generated more than $2 million each month. In addition to damages, closed roads and utility outages forced many businesses to shut their doors. ...

    May 25, 2013 1 Photo

  • Sharing stories of survival

    MOORE — As Monday’s EF-5 tornado moved closer to Plaza Towers Elementary School, teacher Justin Ayers knew they were in its path. Ayers said all of the teachers at the site likely knew what was coming from television reports and they had ...

    May 25, 2013

  • 5-year-old girl finds silver lining

    A twist of fate and the discovery of a cochlear implant from a Moore hospital damaged by Monday’s EF-5 tornado are part of the story of a precious 5-year-old girl. In December, Jayde Scholl was adopted by Tulsa audiologist Jacque Scholl. ...

    May 25, 2013

  • Disaster central

    WASHINGTON — Many states get hit frequently with tornadoes and other natural catastrophes, but Oklahoma is Disaster Central. The twister that devastated Moore was the 74th presidential disaster declared in the Sooner state in the past 60 ...

    May 25, 2013

  • Okla. legislature adjourned early

    OKLAHOMA CITY — Oklahoma lawmakers adjourned the 2013 Legislature on Friday one week earlier than required, wrapping up a session that saw Gov. Mary Fallin advance her agenda to reduce taxes and overhaul the state workers’ compensation ...

    May 25, 2013

  • I-5 bridge falls into river

    MOUNT VERNON — The trucker was hauling a load of drilling equipment when his load bumped against the steel framework over an Interstate 5 bridge. He looked in his rearview mirror and watched in horror as the span collapsed into the water ...

    May 25, 2013

  • Tornadoes impact family twice

    On May 3, 1999, Sherrie Lambert’s sister Esther Coburn, 35, was killed by the devastating EF-5 tornado in Moore....

    May 25, 2013

  • How to help: Community challenge

    Central Oklahoma Habitat for Humanity is challenging the community to provide long-term aid for storm victims by contributing to efforts that will provide many of these Oklahomans with homes....

    May 25, 2013

  • Obama balances threats to America

    WASHINGTON — Forecasting the changing nature of threats against the U.S. for years to come, President Barack Obama says “America is at a crossroads.” And so, too, is his presidency’s counterterrorism policy, which has long struggled to ...

    May 25, 2013

  • Hotels team up to house influx of tornado victims

    Norman hotels are used to big crowds. Whether it’s the extended family of every graduating senior at OU or tens of thousands of visiting Sooner fans, Norman always finds a way to house them....

    May 25, 2013